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Chemical Structure : Orteronel
CAS No.: 566939-85-3
Catalog No.: PC-42626Not For Human Use, Lab Use Only.
A highly selective CYP17A1 (17,20-lyase) inhibitor with IC50 of 17 nM for human 17,20-lyase.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $180 | In stock | |
| 50 mg | $468 | In stock |
Bulk size, bulk discount!
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A highly selective CYP17A1 (17,20-lyase) inhibitor with IC50 of 17 nM for human 17,20-lyase; shows no activity on CYP3A4 (IC50>10 uM) and CYP11B1 (IC50>1 uM); reduces both serum testosterone and dehydroepiandrosterone concentrations in monkey model at a dose of 1mg/kg.
Prostate cancer
Phase 3 Discontinued
| M.Wt | 307.3465 | |
| Formula | C18H17N3O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2-Naphthalenecarboxamide, 6-[(7S)-6,7-dihydro-7-hydroxy-5H-pyrrolo[1,2-c]imidazol-7-yl]-N-methyl- |
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1. Kaku T, et al. Bioorg Med Chem. 2011 Nov 1;19(21):6383-99.
2. Yamaoka M, et al. J Steroid Biochem Mol Biol. 2012 Apr;129(3-5):115-28.
3. Dreicer R, et al. Clin Cancer Res. 2014 Mar 1;20(5):1335-44.
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