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P516-0475

Chemical Structure : P516-0475

CAS No.: 1359627-33-0

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P516-0475

Catalog No.: PC-35094Not For Human Use, Lab Use Only.

P516-0475 is a novel chemical inducer of Streptococcus quorum sensing acts by inhibiting the pheromone-degrading endopeptidase PepO (IC50=10 uM).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    P516-0475 is a novel chemical inducer of Streptococcus quorum sensing acts by inhibiting the pheromone-degrading endopeptidase PepO (IC50=10 uM).
    P516-0475 specifically induces expression of Rgg2/3-regulated genes in the presence of SHP pheromones at concentrations lower than typically required for QS induction.
    P516-0475 directly inhibits recombinant PepO in vitro as an uncompetitive inhibitor, induces QS by stabilizing SHP pheromones in culture.

    Physicochemical Properties

    M.Wt 315.333
    Formula C15H17N5O3
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-(3-methoxypropyl)-7-methyl-4-oxo-4,5-dihydro-[1,2,3]triazolo[1,5-a]quinoxaline-3-carboxamide

    References

    1. Pérez Morales TG, et al. J Biol Chem. 2018 Jan 19;293(3):931-940.

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