Chemical Structure : P626
CAS No.:
2586198-02-7
P626
Catalog No.: PC-25759Not For Human Use, Lab Use Only.
P626 is a potent, selective dual adenosine A2A/A2B receptor (A2AR/A2BR) antagonist with IC50 of 5.73 nM and 34 nM at both hA2AAR and hA2BAR (cAMP assay), with no significant acitivity against hA1AR and hA3AR.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
P626 is a potent, selective dual adenosine A2A/A2B receptor (A2AR/A2BR) antagonist with IC50 of 5.73 nM and 34 nM at both hA2AAR and hA2BAR (cAMP assay), with no significant acitivity against hA1AR and hA3AR.
P626 efficiently prevented A2AR- and A2BR-dependent responses in OPCs, a mechanism consistent with its protective effects in EAE mice.
P626 treatment mitigated myelin loss and restored basal myelin levels in spinal cord samples from EAE mice.
Physicochemical Properties
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M.Wt
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416.47
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Formula
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C17H16N6O3S2
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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4-(2-((7-Amino-2-(furan-2-yl)thiazolo[5,4-d]pyrimidin-5-yl)amino)ethyl)benzenesulfonamide
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References
1. F. Varano, et al. Bioorganic & Medicinal Chemistry Letters 30 (2020): 127067.
2. M Morozzi, et al. J Cell Mol Med. 2025 Nov;29(22):e70952.
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