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Chemical Structure : PA-8
Catalog No.: PC-72883Not For Human Use, Lab Use Only.
PA-8 (PAC1 antagonist PA-8) is a potent, pecific small molecule antagonist of PACAP type I (PAC1) receptor.
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PA-8 (PAC1 antagonist PA-8) is a potent, pecific small molecule antagonist of PACAP type I (PAC1) receptor.
PA-8 (1 nM) significantly and dose dependently attenuated PACAP (1 nM)-induced CREB phosphorylation in the CHO cells expressing PAC1, but not CHO cells expressing VPAC1, or VPAC2 receptors.
PA-8 also dose dependently inhibited PACAP-induced cAMP elevation with an IC50 of 2 nM.
PA-8 blocked PACAP-induced aversive responses and mechanical allodynia in mice.
| M.Wt | 342.36 | |
| Formula | C17H18N4O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Takasaki I, et al. J Pharmacol Exp Ther. 2018 Apr;365(1):1-8.
2. Takasaki I, et al. J Pharmacol Sci. 2019 Feb;139(2):129-132.
3. Shibato J, et al. Neural Plast. 2021 Aug 7;2021:2522454.
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