PA452 | RXR antagonist | Probechem Biochemicals

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Chemical Structure : PA452

CAS No.: 457657-34-0

PA452 (PA-452)

Catalog No.: PC-20831Not For Human Use, Lab Use Only.

PA452 is a specific antagonist of retinoic X receptor (RXR) with pA2 value of 7.11.

Packing	Price	Stock
5 mg	$198	In stock
10 mg	$298	In stock
25 mg	$498	In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

PA452 is a specific antagonist of retinoic X receptor (RXR) with pA2 value of 7.11.
PA452 inhibits the effect of Retinoic acid (RA) on Th1/Th2 development, inhibits the Troglitazone (TZ)-induced CK13 expression

Physicochemical Properties

M.Wt	439.60
Formula	C26H37N3O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	2-((3-(hexyloxy)-5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)(methyl)amino)pyrimidine-5-carboxylic acid

References

1. Fujii S., et al. Bioorg. Med. Chem. Lett. 2010;20:5139–5142.

2. wata M, et al. Int Immunol. 2003 Aug;15(8):1017-25.

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PA452 (PA-452)

Biological Activity

Physicochemical Properties

References

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