PAD inhibitor 4f

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Chemical Structure : PAD inhibitor 4f

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Catalog No.: PC-25372Not For Human Use, Lab Use Only.

PAD inhibitor 4f is a potent peptidylarginine deiminases (PAD) inhibitor with IC50 of 23 nM and 10 nM for PAD2 and PAD4 respectively, demonstrates potent inhibition of PAD-mediated citrullination in human and rat neutrophils (IC50=30 nM).

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

Physicochemical Properties

M.Wt	524.45
Formula	C26H27Cl2N7O
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-2-amino-2-(1-(5-(3,5-dichloro-6-(1-methyl-1H-pyrazol-3-yl)pyridin-2-yl)isoquinolin-1-yl)piperidin-4-yl)-N-methylacetamide

References

1. Schnute ME, et al. ACS Med Chem Lett. 2025 Jul 9;16(8):1662-1669.

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PAD inhibitor 4f

Biological Activity

Physicochemical Properties

References

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