Chemical Structure : PAMT-001
CAS No.:
PAMT-001
(PAMT001)
Catalog No.: PC-26466Not For Human Use, Lab Use Only.
PAMT-001 is a potent inverse agonist of ERRα with EC50 of 0.17 uM, effectively binds to the ERRα ligand-binding domain, interacts with and inhibits ERRα through cooperation with PGC1α, effectively suppresses tumorigenesis.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
PAMT-001 is a potent inverse agonist of ERRα with EC50 of 0.17 uM, effectively binds to the ERRα ligand-binding domain, interacts with and inhibits ERRα through cooperation with PGC1α, effectively suppresses tumorigenesis.
PAMT-001 is potently cytotoxic against various cancer cell lines through mitochondria mediated apoptosis.
PAMT-001 inhibits mtOXPHOS and impairs mitochondrial respiration in various cancer cells.
PAMT-001 triggers autophagy for CHOP signaling and apoptosis.
PAMT-001 induces pyroptotic cell death via GSDME cleavage.
PAMT-001 inhibited tumor growth without causing toxicity in colorectal cancer xenograft model.
Physicochemical Properties
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M.Wt
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434.34
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Formula
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C18H16F6N4O2
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(E)-2-(4-((2,4-bis(trifluoromethyl)benzyl)oxy)-3-methoxybenzylidene)hydrazine-1-carboximidamide
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References
1. Seo W, et al. Cell Death Discov. 2026 Mar 26. doi: 10.1038/s41420-026-03010-4.
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