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Chemical Structure : PARP-1 inhibitor Pip6
Catalog No.: PC-49753Not For Human Use, Lab Use Only.
PARP-1 inhibitor Pip6 is an analog of PARP-1 type I inhibitor AZ0108, shows similar type I inhibition of PARP-1 but is 90-fold more cytotoxic than AZ0108.
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PARP-1 inhibitor Pip6 is an analog of PARP-1 type I inhibitor AZ0108, shows similar type I inhibition of PARP-1 but is 90-fold more cytotoxic than AZ0108.
The enhanced cytotoxicity of Pip6 compared with AZ0108 is due to prolonged target residence time on PARP-1.
Pip6 represents a new class of PARP-1 inhibitors that may have unique anticancer properties.
| M.Wt | 482.47 | |
| Formula | C24H21F3N6O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Moriah R Arnold, et al. Cell Chem Biol. 2022 Dec 15;29(12):1694-1708.e10.
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