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Chemical Structure : PAV-206
Catalog No.: PC-49168Not For Human Use, Lab Use Only.
PAV-206 is a novel potent antiretroviral chemotype that inhibits HIV-1 replication with EC50 of 34 nM in HIV-1-infected MT-2 T cells, and 75 nM in HIV-1-infected peripheral blood mononuclear cells (PBMCs), inhibits HIV-1 replication by interfering with HIV-1 assembly.
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PAV-206 is a novel potent antiretroviral chemotype that inhibits HIV-1 replication with EC50 of 34 nM in HIV-1-infected MT-2 T cells, and 75 nM in HIV-1-infected peripheral blood mononuclear cells (PBMCs), inhibits HIV-1 replication by interfering with HIV-1 assembly.
PAV-206 acts on the host RNA-granule-related RNP complex that is the precursor of assembly intermediates, even in the absence of Gag, colocalizes with both of host enzymes, ABCE1 and DDX6, in the absence of HIV-1 infection.
PAV-206 is a first-in-class selective inhibitor of HIV-1 assembly that inhibits HIV-1 virus production by selectively acting on host-protein-containing capsid assembly intermediates.
| M.Wt | 445.559 | |
| Formula | C28H31NO4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. J Virol. 2021 Jan 13;95(3):e00883-20.
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