Catalog No.: PC-22550Not For Human Use, Lab Use Only.
PAV-431 is a small molecule pan-respiratory viral assembly modulator with EC50 of <100 nM against multiple viruses in cell culture, directly binds to host protein 14-3-3.
PAV-431 is a small molecule pan-respiratory viral assembly modulator with EC50 of <100 nM against multiple viruses in cell culture, directly binds to host protein 14-3-3.
PAV-431 displayed an EC50 between 25 nM and 100 nM (depending on the virus) against members of Orthomyxoviridae, Coronaviridae, Paramyxoviridae, Adenoviridae, Herpesviridae, and Picornaviridae-all six families of viruses which cause respiratory disease in humans.
PAV-431 shows efficacy against the WA 1/2020, delta, and omicron strains of SARS CoV-2.
PAV-431 does not show significant activity against rabies virus.
PAV-431 treatment exhibits statistically significant drop in RSV titer in cotton rats infected with respiratory syncytial virus (RSV).
