Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : PB28 dihydrochloride
CAS No.: 172907-03-8
Catalog No.: PC-60346Not For Human Use, Lab Use Only.
PB28 dihydrochloride is a potent, mixed sigma2 agonist and sigma1 antagonist with Ki of 0.28 and 13.0 nM, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $128 | In stock | |
| 10 mg | $188 | In stock | |
| 25 mg | $298 | In stock | |
| 50 mg | $498 | In stock | |
| 100 mg | Get quote |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
PB28 dihydrochloride is a potent, mixed sigma2 agonist and sigma1 antagonist with Ki of 0.28 and 13.0 nM, respectively.
PB28 inhibits cancer cell growth, modulates P-glycoprotein, and synergizes with doxorubicin in MCF7 and MCF ADR cells with IC50 in nanomolar range.
PB28 increases G0-G1-phase fraction and caspase-independent apoptosis, also reduces P-gp expression.
| M.Wt | 443.5 | |
| Formula | C24H40Cl2N2O | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
1-Cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine dihydrochloride |
|
1. Azzariti A, et al. Mol Cancer Ther. 2006 Jul;5(7):1807-16.
2. Cassano G, et al. Cell Calcium. 2006 Jul;40(1):23-8.
3. Berardi F, et al. J Med Chem. 1996 Jan 5;39(1):176-82.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
