Chemical Structure : PC945
Catalog No.: PC-62615Not For Human Use, Lab Use Only.
Opelconazole (PC945) is a novel broad spectrum antifungal agent that potently inhibits Aspergillus fumigatus sterol 14α-demethylase (CYP51A and CYP51B) with IC50 of 0.23 and 0.22 uM, respectively.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Opelconazole (PC945) is a novel broad spectrum antifungal agent that potently inhibits Aspergillus fumigatus sterol 14α-demethylase (CYP51A and CYP51B) with IC50 of 0.23 and 0.22 uM, respectively.
Opelconazole (PC945) shows MIC values 0.032 to >8 ug/ml against 96 clinically isolated A. fumigatus strains, demonstrates activity against itraconazole-susceptible and -resistant A. fumigatus growth with IC50 of 0.0012 to 0.034 ug/ml.
Opelconazole (PC945) is a broad spectrum of pathogenic fungi with MIC 0.0078 to 2 ug/ml, and exhibits activity in vivo.
M.Wt | 682.748 | |
Formula | C38H37F3N6O3 | |
Appearance | Solid | |
Storage |
|
|
Solubility |
10 mM in DMSO |
1. Colley T, et al. Antimicrob Agents Chemother. 2017 Apr 24;61(5). pii: e02280-16.
2. Kimura G, et al. Antimicrob Agents Chemother. 2017 Aug 24;61(9). pii: e00124-17.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright