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PCC-0105002

Chemical Structure : PCC-0105002

CAS No.:

PCC-0105002

Catalog No.: PC-47005Not For Human Use, Lab Use Only.

PCC-0105002 is a novel small molecule inhibitor of PSD95-nNOS protein-protein interaction with IC50 of 1.4 uM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

PCC-0105002 is a novel small molecule inhibitor of PSD95-nNOS protein-protein interaction with IC50 of 1.4 uM.
PCC-0105002 suppressed mechanical allodynia, thermal hyperalgesia, and abnormal dorsal horn wide dynamic range neuron discharge in the rat spinal nerve ligation (SNL) model.
PCC-0105002 altered signaling downstream of NMDAR and thus functionally and structurally attenuating synaptic plasticity through respective regulation of the NR2B/GluR1/CaMKIIα and Rac1/RhoA pathways.
PCC-0105002 attenuated neuropathic pain without inducing motor dysfunction in animal model.
PCC-0105002 disrupted the PSD95-nNOS interaction in vitro and in vivo.

Physicochemical Properties

M.Wt 450.356
Formula C23H25Cl2NO4
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name

References

1. Zhihong Sun, et al. Toxicol Appl Pharmacol. 2021 Oct 15;429:115698.

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