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Chemical Structure : PCC0208057
Catalog No.: PC-22083Not For Human Use, Lab Use Only.
PCC0208057 is a potent, selective TRPC6 channel inhibitor, inhibits TRPC6-mediated Ca2+ concentration increase with IC50 of 2.44 uM, binds directly to TRPC6.
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PCC0208057 is a potent, selective TRPC6 channel inhibitor, inhibits TRPC6-mediated Ca2+ concentration increase with IC50 of 2.44 uM, binds directly to TRPC6.
PCC0208057 inhibits the proliferation of prostate cancer cells, induces cell cycle arrest at G2/M phase.
PCC0208057 increases the phosphorylation of NFAT and Cdc2, inhibits the migration of prostate cancer cells.
PCC0208057 inhibits the invasion and metastasis of prostate cancer cells.
PCC0208057 (50 mg/kg and 100 mg/kg) has good antitumor efficacy in nude mice.
| M.Wt | 425.50 | |
| Formula | C22H23N3O4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Yingjie Wei, et al. Front Pharmacol. 2024 Mar 18:15:1352373.
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