Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : PCCR-1
Catalog No.: PC-38747Not For Human Use, Lab Use Only.
PCCR-1 is a potent, specific RORγ inhibitor with binding IC50 of 34.45 nM and 778.1 nM for human and mouse RORγ, respectively, > 300-fold selectivity over other isoforms of ROR.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
PCCR-1 is a potent, specific RORγ inhibitor with binding IC50 of 34.45 nM and 778.1 nM for human and mouse RORγ, respectively, > 300-fold selectivity over other isoforms of ROR.
PCCR-1 demonstrates promising potency for IL-17A inhibition in human and canine PBMCs and mouse splenocytes with no significant impact on Th1 and Th2 cytokines.
PCCR-1 exhibits significant efficacy in the acute CS model with dose-dependent inhibition of the PD biomarkers, effectively inhibited IL-17A release in whole blood and BALf samples from COPD patients.
| M.Wt | 541.614 | |
| Formula | C28H29F2N3O4S | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
1. Desai H, et al. Sci Rep. 2022 May 24;12(1):8744.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
