PCSK9 inhibitor 9 |CAS:2215931-60-3 Probechem Biochemicals

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Chemical Structure : PCSK9 inhibitor 9

PCSK9 inhibitor 9

Catalog No.: PC-38279Not For Human Use, Lab Use Only.

PCSK9 inhibitor 9 is a small-molecule ligand with high affinity for a novel allosteric binding site on PCSK9.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

PCSK9 inhibitor 9 is a small-molecule ligand with high affinity for a novel allosteric binding site on PCSK9.
PCSK9 inhibitor 9 showed good target engagement with PCSK9 in Huh7 cell lysate.

Physicochemical Properties

M.Wt	631.719
Formula	C34H34FN3O6S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	2'-fluoro-4'-(((1R)-1-methyl-1-(2-oxo-2-(thiazol-2-ylamino)ethyl)-6-((tetrahydro-2H-pyran-2-yl)methoxy)-1,2,3,4-tetrahydroisoquinolin-7-yl)oxy)-[1,1'-biphenyl]-4-carboxylic acid

References

1. Whitney L Petrilli, et al. Cell Chem Biol. 2020 Jan 16;27(1):32-40.e3.

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