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Chemical Structure : PCSK9 modulator 10
Catalog No.: PC-63170Not For Human Use, Lab Use Only.
PCSK9 modulator 10 is a highly potent, orally active PCSK9 modulator that inhibits PCSK9 production in HepG2 cells with IC50 of 0.036 nM.
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PCSK9 modulator 10 is a highly potent, orally active PCSK9 modulator that inhibits PCSK9 production in HepG2 cells with IC50 of 0.036 nM.
PCSK9 modulator 10 significantly reduces LDL-c levels by 46% and 57% at 0.01 and 0.04 mg/kg in vivo without deaths or abnormal general signs.
| M.Wt | 365.659 | |
| Formula | C15H6ClF6NO | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Daniel Pettersen, et al. Small molecule modulators of PCSK9-a literature and patent overview. Bioorg Med Chem Lett. 2018 Feb 26. pii: S0960-894X(18)30151-3.
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