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PCW-A1001

Chemical Structure : PCW-A1001

CAS No.:

PCW-A1001

Catalog No.: PC-20211Not For Human Use, Lab Use Only.

PCW-A1001 is a potent, selective inhibitor of FLT-3 (D835Y) mutant with IC50 of 764 nM, weakly inhibits WT FLT-3 with IC50 of 2.54 uM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

PCW-A1001 is a potent, selective inhibitor of FLT-3 (D835Y) mutant with IC50 of 764 nM, weakly inhibits WT FLT-3 with IC50 of 2.54 uM.
PCW-A1001 inhibited the proliferation of MV4-11 cells with IC50 of 1.98 uM.

Physicochemical Properties

M.Wt 394.52
Formula C23H30N4O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

4-(tert-butyl)-N-(4-carbamoyl-3-(piperidin-3-ylamino)phenyl)benzamide

References

1. Seong Hun Jang, et al. Front Mol Biosci. 2022 Nov 25;9:1072028.

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