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Chemical Structure : PD-L1 inhibitor S4-1
Catalog No.: PC-49504Not For Human Use, Lab Use Only.
PD-L1 inhibitor S4-1 is a novel small-molecule inhibitor of PD-L1, effectively alters the PD-L1/PD-1 interaction, induces PD-L1 dimerization and internalization.
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PD-L1 inhibitor S4-1 is a novel small-molecule inhibitor of PD-L1, effectively alters the PD-L1/PD-1 interaction, induces PD-L1 dimerization and internalization.
S4-1 improved PD-L1 localization to endoplasmic reticulum, and thus enhanced the cytotoxicity of peripheral blood mononuclear cells toward tumor cells.
S4-1 significantly inhibited tumor growth in both lung and colorectal cancer models, particularly in colorectal cancer, where it led to complete clearance of a portion of the tumor cells.
S4-1 induced T-cell activation and inversed the inhibitory tumor microenvironment, consistent with the PD-L1/PD-1 pathway blockade.
| M.Wt | 460.49 | |
| Formula | C26H24N2O6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Sun C, et al. J Med Chem. 2022 Dec 29. doi: 10.1021/acs.jmedchem.2c01801.
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