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Chemical Structure : PD089828
CAS No.: 179343-17-0
Catalog No.: PC-38509Not For Human Use, Lab Use Only.
PD089828 is an ATP competitive inhibitor of FGFR-1, PDGFR-β and EGFR with IC50 of 0.15 uM, 1.76 uM, and 5.47 uM, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $158 | In stock | |
| 25 mg | $268 | In stock | |
| 50 mg | $458 | In stock | |
| 100 mg | $788 | In stock | |
| 1 g | Get quote |
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PD089828 is an ATP competitive inhibitor of FGFR-1, PDGFR-β and EGFR with IC50 of 0.15 uM, 1.76 uM, and 5.47 uM, respectively.
PD089828 inhibits PDGF receptor autophosphorylation in VSMC, also inhibits the PDGF-induced tyrosine phosphorylation of the 44- and 42-kDa mitogen-activated protein kinase isoforms.
PD089828 inhibits PDGF-directed migration, serum-stimulated growth of VSMC, and PDGF receptor autophosphorylation with IC50 of 0.8, 4.5 and 1.8 uM, respectively.
| M.Wt | 405.28 | |
| Formula | C18H18Cl2N6O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
N-[2-Amino-6-(2,6-dichlorophenyl)pyrido[2,3-d]pyrimidin-7-yl]-N′-(1,1-dimethylethyl)urea |
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1. J M Hamby, et al. J Med Chem. 1997 Jul 18;40(15):2296-303.
2. Dahring TK, et al. J Pharmacol Exp Ther. 1997 Jun;281(3):1446-56.
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