Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : PDE-I2
Catalog No.: PC-72859Not For Human Use, Lab Use Only.
PDE-I2 is a potent and selective inhibitor of malaria proliferation with Pf IC50 of 18 nM.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
PDE-I2 is a potent and selective inhibitor of malaria proliferation with Pf IC50 of 18 nM.
PDE-I2 is a precursor of the anticancer duocarmycin family that preserves the class's sequence-specific DNA binding but lacks its signature DNA alkylating cyclopropyl warhead.
PDE-I2 retains comparable antimalarial potency to chloroquine.
PDE-I2 is >1,000-fold less toxic to human cell lines than duocarmycin, with mitigated impacts on eukaryotic chromosome stability.
PDE-I2 treatment induces severe defects in parasite nuclear segregation leading to impaired daughter cell formation during schizogony.
| M.Wt | 521.486 | |
| Formula | C25H23N5O8 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
|
|
1. Arne Alder, et al. Cell Chem Biol. 2021 Oct 23;S2451-9456(21)00439-6.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
