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PDE10A-IN-31

Chemical Structure : PDE10A-IN-31

CAS No.: 1639889-98-7

PDE10A-IN-31

Catalog No.: PC-62737Not For Human Use, Lab Use Only.

PDE10A-IN-31 is a potent, highly selective PDE10A inhibitor with IC50 of 2 nM for both rPDE10A and hPDE10A.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

PDE10A-IN-31 is a potent, highly selective PDE10A inhibitor with IC50 of 2 nM for both rPDE10A and hPDE10A; dispalys >2,000-fold selective over PDE1B/2A/3B/4D/5A/7A9A, weak activity on CYP isoforms; displays excellent pharmacokinetic properties.

Physicochemical Properties

M.Wt 477.524
Formula C28H23N5O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(E)-4-(8-morpholino-2-(2-(quinolin-2-yl)vinyl)imidazo[1,2-b]pyridazin-3-yl)benzoic acid

References

1. Meegalla SK, et al. Bioorg Med Chem Lett. 2016 Sep 1;26(17):4216-22.

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