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Chemical Structure : PDE4 inhibitor Compound A
Catalog No.: PC-20471Not For Human Use, Lab Use Only.
PDE4 inhibitor Compound A is a potent, highly selective PDE4 inhibitor with IC50 of 1.1 nM (PDE4B2), weakly inhibits PDE3 (IC50=150 nM) and does not inhibit other PDE subtypes.
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PDE4 inhibitor Compound A is a potent, highly selective PDE4 inhibitor with IC50 of 1.1 nM (PDE4B2), weakly inhibits PDE3 (IC50=150 nM) and does not inhibit other PDE subtypes.
Compound A (1-10 mg/kg, QD, p.o.) showed dose-dependent and significant suppressive effects on glycosylated hemoglobin (GHb) and urinary albumin/creatinine ratio (UACR) in UNx-db/db mice.
Compound A suppressed pro-fibrotic and pro-inflammatory marker mRNAs and increased anti-reactive oxygen species marker mRNAs in the kidneys of UNx-db/db mice.
| M.Wt | 436.51 | |
| Formula | C24H28N4O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Mitsugi Ookawara, et al. Eur J Pharmacol. 2021 Mar 5;894:173852.
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