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PDE8 inhibitor 15

Chemical Structure : PDE8 inhibitor 15

CAS No.:

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PDE8 inhibitor 15

Catalog No.: PC-23488Not For Human Use, Lab Use Only.

PDE8 inhibitor 15 is a potent, selective phosphodiesterase 8A (PDE8A) inhibitor with IC50 of 11 nM (PDE8A), high selectivity over other PDEs.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    PDE8 inhibitor 15 is a potent, selective phosphodiesterase 8A (PDE8A) inhibitor with IC50 of 11 nM (PDE8A), high selectivity over other PDEs.
    PDE8 inhibitor 15 (2.5 mg/kg and 5.0 mg/kg, p.o.) significantly improved the cAMP level of the right brain and exhibited dose-dependent effects on cognitive improvement in a vascular dementia (VaD) mouse model.

    Physicochemical Properties

    M.Wt 405.74
    Formula C15H12ClF4N5O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    2-chloro-9-(3-(2,2-difluoroethoxy)-5-(difluoromethoxy)benzyl)-9H-purin-6-amine

    References

    1. Wu XN, et al. Acta Pharm Sin B. 2022 Jul;12(7):3103-3112.

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