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PELI1-IN-1

Chemical Structure : PELI1-IN-1

CAS No.: 3034889-94-3

PELI1-IN-1 (Compound 3d)

Catalog No.: PC-26725Not For Human Use, Lab Use Only.

PELI1-IN-1 (PELI1 inhibitor 3d) is a specific small molecule inhibitor of E3 ubiquitin ligase Pellino-1 (PELI1) with binding Kd of 8.2 uM in fluorescence quenching assays, interrupts the interaction of PELI1 and SNAIL/SLUG.

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Biological Activity

PELI1-IN-1 (PELI1 inhibitor 3d) is a specific small molecule inhibitor of E3 ubiquitin ligase Pellino-1 (PELI1) with binding Kd of 8.2 uM in fluorescence quenching assays, interrupts the interaction of PELI1 and SNAIL/SLUG.
PELI1-IN-1 exhibits potent anti-TNBC activity against cell migration without affecting cell proliferation in vitro.
PELI1-IN-1 shows potent anti-TNBC metastasis efficacy without observable toxic side effects in vivo.

Physicochemical Properties

M.Wt 320.34
Formula C20H16O4
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(E)-3'-(3,5-dihydroxystyryl)-[1,1'-biphenyl]-3,4'-diol

References

1. Guangsen Xu, et al. Eur J Med Chem. 2023 Dec 20:265:116060.

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