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Chemical Structure : PERK activator MK-28
CAS No.: 864388-65-8
Catalog No.: PC-72030Not For Human Use, Lab Use Only.
PERK activator MK-28 is a potent, selective small molecule PERK activator with EC50 of 490 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $198 | In stock | |
| 10 mg | $318 | In stock | |
| 25 mg | $528 | In stock | |
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| 100 mg | Get quote |
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PERK activator MK-28 is a potent, selective small molecule PERK activator with EC50 of 490 nM.
MK-28 shows little or no effect on EIF2AK1 (HRI) or EIF2AK2 (PKR), weakly activated EIF2AK4 (GCN2) with EC50 of 3.5 uM, also displays high selectivity on a panel of 391 kinases.
MK-28 rescues cells from ER stress-induced apoptosis.
MK-28 is predicted to interact with the PERK activation loop and its cellular protective effect is PERK-dependent and more potent than CCT020312.
MK-28 exhibits brain penetrance and improves neurological functions in the R6/2 HD mouse model.
MK-28 improves systemic function and survival in R6/2 mice and induces increased levels of eIF2α-P in the mouse brain striatum.
| M.Wt | 396.45 | |
| Formula | C24H20N4O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Benzaldehyde, 3,4-dihydroxy-, 2-(4,6-diphenyl-2-pyrimidinyl)-2-methylhydrazone |
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1. Javier Ganz, et al. Sci Rep. 2020 Apr 23;10(1):6875.
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