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Chemical Structure : PF-00835231
CAS No.: 870153-29-0
Catalog No.: PC-72752Not For Human Use, Lab Use Only.
PF-00835231 (PF00835231) is a potent inhibitor of pan-coronavirus family 3CL pro (IC50=0.27 nM, SARS CoV-2), with selectivity over human host protease targets
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $128 | In stock | |
| 10 mg | $198 | In stock | |
| 25 mg | $328 | In stock | |
| 50 mg | $528 | In stock | |
| 100 mg | Get quote |
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PF-00835231 (PF00835231) is a potent inhibitor of pan-coronavirus family 3CL pro (IC50=0.27 nM, SARS CoV-2), with selectivity over human host protease targets.
PF-00835231 inhibits SARS CoV-1 3CL pro with IC50 of 4 nM, displaying IC50 values of >10 μM against many of the other proteases and possessing modest levels of inhibition of cathepsin B (IC50 = 1.3 μM) and rhinovirus 3Cpro (IC50 = 1.7 μM).
PF-00835231 demonstrated potent inhibitory activity against all tested coronavirus 3CLpro including members of alpha-coronaviruses (NL63-CoV, HCoV-229E, PEDV, FIPV), beta-coronaviruses (HKU4-CoV, HKU5-CoV, HKU9-CoV, MHV-CoV, OC43-CoV, HKU1-CoV), and gamma-coronavirus (IBV-CoV), with Ki values ranging from 30 pM to 4 nM.
PF-00835231 exhibited viral effect against SARS-CoV-2 in cell culture, also showed potential synergy with remdesivir in HeLa-ACE2 cells.
PF-00835231 demonstrateed in vivo effect in mouse models of SARS-CoV and SARS-CoV-2 infection.
| M.Wt | 472.542 | |
| Formula | C24H32N4O6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
N-((S)-1-(((S)-4-Hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)-4-methoxy-1H-indole-2-carboxamide |
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1. de Vries M, et al. J Virol. 2021 Feb 23;95(10):e01819-20.
2. Liu C, et al. Antiviral Res. 2021 Mar;187:105020.
3. Hoffman RL, et al. J Med Chem. 2020 Nov 12;63(21):12725-12747.
4. Robert L Hoffman, et al. J Med Chem. 2020 Nov 12;63(21):12725-12747.
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