Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : PF-02413873
Catalog No.: PC-61896Not For Human Use, Lab Use Only.
PF-02413873 (PF-2413873) is a potent, selective, fully competitive, and orally active progesterone receptor (PR) antagonist with Ki of 9.7 nM.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
PF-02413873 (PF-2413873) is a potent, selective, fully competitive, and orally active progesterone receptor (PR) antagonist with Ki of 9.7 nM; displays >30-fold selectivity over other homologous nuclear hormone receptors, GR, AR, and MR; blocks the follicular phase increase in endometrial thickness, the midcycle lutenizing hormone surge, and elevation in estradiol in a dose-dependent fashion compared with placebo in clinical trials.
Other Indication
Phase 1 Discontinued
| M.Wt | 359.44 | |
| Formula | C18H21N3O3S | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
1. Bungay PJ, et al. Drug Metab Dispos. 2011 Aug;39(8):1396-405.
2. Howe DC, et al. J Pharmacol Exp Ther. 2011 Nov;339(2):642-53.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
