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Chemical Structure : PF-03049423
Catalog No.: PC-61858Not For Human Use, Lab Use Only.
PF-03049423 is a potent, selective, orally active, and brain penetrant inhibitor of PDE5 with IC50 of 0.2 nM.
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PF-03049423 is a potent, selective, orally active, and brain penetrant inhibitor of PDE5 with IC50 of 0.2 nM; displays 158-fold and 2460-fold selectivity over PDE6 and PDE11, respectively; possesses an excellent potency and selectivity profile and demonstrates robust in vivo blood pressure lowering in a spontaneously hypertensive rat (SHR) model.
Stroke
Phase 2 Discontinued
| M.Wt | 468.55 | |
| Formula | C24H32N6O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Hughes RO, et al. J Med Chem. 2010 Mar 25;53(6):2656-60.
2. Di Cesare F, et al. J Stroke Cerebrovasc Dis. 2016 Mar;25(3):642-9.
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