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Chemical Structure : PF-04191834
Catalog No.: PC-61882Not For Human Use, Lab Use Only.
PF-04191834 (PF-4191834) is a potent, non‐iron chelating, non‐redox, selective and competitive inhibitor of 5-lipoxygenase (5‐LO) with Ki of 10 nM.
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PF-04191834 (PF-4191834) is a potent, non‐iron chelating, non‐redox, selective and competitive inhibitor of 5-lipoxygenase (5‐LO) with Ki of 10 nM; displays 300‐fold over 12‐LO and 15‐LO, and no inhibition of the cyclooxygenase enzymes; is under clinical investigation for the oral treatment of asthma and pain.
Pain
Phase 2 Discontinued
| M.Wt | 393.502 | |
| Formula | C22H23N3O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Masferrer JL, et al. J Pharmacol Exp Ther. 2010 Jul;334(1):294-301.
2. Rzodkiewicz P, et al. Reumatologia. 2016;54(4):161-164. Epub 2016 Oct 5.
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