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PF-04449613

Chemical Structure : PF-04449613

CAS No.: 1236858-52-8

PF-04449613 (PF-9613, PF04449613, PF 04449613)

Catalog No.: PC-35833Not For Human Use, Lab Use Only.

PF-04449613 (PF-9613, PF04449613, PF 04449613) is a potent and selective inhibitor of PDE9 with IC50 of 22 nM, >50-fold selective over PDE1C (IC50>1000 nM).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    PF-04449613 (PF-9613, PF04449613, PF 04449613) is a potent and selective inhibitor of PDE9 with IC50 of 22 nM, >50-fold selective over PDE1C (IC50>1000 nM).

    Physicochemical Properties

    M.Wt 395.463
    Formula C21H25N5O3
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    6-[(1R)-1-(3-phenoxyazetidin-1-yl)ethyl]-1-(tetrahydro-2H-pyran-4-yl)-1,5- dihydro-4H-pyrazolo [3,4-d] pyrimidin-4-one

    References

    1. Lai B, et al. Dev Neurobiol. 2018 Sep;78(9):859-872.
    2. Michelle M Claffey, et al. J Med Chem. 2012 Nov 8;55(21):9055-68.

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