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Chemical Structure : PF-04827736
Catalog No.: PC-63527Not For Human Use, Lab Use Only.
PF-04827736 ((S)-PF-04677490) is a potent, selective PDE1 inhibitor with IC50 of 42, 9.1 and 38 nM for PDE1A, PDE1B and PDE1C, respectively.
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PF-04827736 ((S)-PF-04677490) is a potent, selective PDE1 inhibitor with IC50 of 42, 9.1 and 38 nM for PDE1A, PDE1B and PDE1C, respectively.
PF-04827736 displays >10-fold selectivity over PDE10A1, and >45-fold selectivity over other PDE isoforms.
| M.Wt | 327.388 | |
| Formula | C17H21N5O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Humphrey JM, et al. J Med Chem. 2018 May 10. doi: 10.1021/acs.jmedchem.8b00374.
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