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Chemical Structure : PF-04991532
Catalog No.: PC-61880Not For Human Use, Lab Use Only.
PF-04991532 (PF4991532) is a potent, hepatoselective Glucokinase (GK) activator with EC50 of 90±45 nM.
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PF-04991532 (PF4991532) is a potent, hepatoselective Glucokinase (GK) activator with EC50 of 90±45 nM; displays >50-fold liver-to-pancreas ratio of tissue distribution in rodent and non-rodent species; robustly lowers fasting and postprandial glucose with no hypoglycemia in vivo.
Diabetes
Phase 1 Discontinued
| M.Wt | 396.37 | |
| Formula | C18H19F3N4O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Pfefferkorn JA, et al. J Med Chem. 2012 Feb 9;55(3):1318-33.
2. Erion DM, et al. PLoS One. 2014 May 23;9(5):e97139.
3. Ghosh A, et al. Drug Metab Dispos. 2014 Oct;42(10):1599-610.
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