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Chemical Structure : PF-05085727
Catalog No.: PC-61126Not For Human Use, Lab Use Only.
A potent, selective, brain penetrant phosphodiesterase 2A (PDE2A) inhibitor with IC50 of 2 nM, >4,000-fold selectivity over PDE1 and PDE3-11.
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A potent, selective, brain penetrant phosphodiesterase 2A (PDE2A) inhibitor with IC50 of 2 nM, >4,000-fold selectivity over PDE1 and PDE3-11; increases brain cGMP accumulation in rodent brain regions expressing highest levels of PDE2A, demonstrates in vivo activity for clinical cognition indications.
| M.Wt | 413.408 | |
| Formula | C20H18F3N7 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Helal CJ, et al. J Med Chem. 2017 Jul 13;60(13):5673-5698.
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