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PF-06260933

Chemical Structure : PF-06260933

CAS No.: 1811510-56-1

PF-06260933 (PF 6260933;PF6260933)

Catalog No.: PC-60014Not For Human Use, Lab Use Only.

PF-06260933 (PF06260933,PF6260933) is a potent, selective, orally available MAP4K4 inhibitor with IC50 of 3.7 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

PF-06260933 (PF06260933, PF6260933) is a potent, selective, orally available MAP4K4 inhibitor with IC50 of 3.7 nM.
PF-06260933 demonstrates very good selectivity against more than 150 native kinases, with only the closely related GCK family members (ZC2, TNIK and ZC3, MINK 70% inhibition at 1 uM).
PF-06260933 inhibits LPS-induced plasma TNFα levels in mouse model.

Physicochemical Properties

M.Wt 296.754
Formula C16H13ClN4
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

5-(4-chlorophenyl)-[3,3'-bipyridine]-6,6'-diamine

References

1. Ammirati M, et al. ACS Med Chem Lett. 2015 Oct 6;6(11):1128-33.

2. Roth Flach RJ, et al. Nat Commun. 2015 Dec 21;6:8995.

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