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Chemical Structure : PF-06260933 dihydrochloride
Catalog No.: PC-61694Not For Human Use, Lab Use Only.
PF-06260933 dihydrochloride is a potent, selective and orally bioavailable MAP4K4 inhibitor with kinase IC50 of 3.7 nM, cell IC50 of 160 nM.
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PF-06260933 dihydrochloride is a potent, selective and orally bioavailable MAP4K4 inhibitor with kinase IC50 of 3.7 nM, cell IC50 of 160 nM.
PF-06260933 dihydrochloride possesses excellent kinome selectivity and suitable properties for in vivo pharmacological characterization.
PF-06260933 dihydrochloride significantly improves fasting hyperglycemia (44% reduction in blood glucose, 10 mg/kg, bid); also markedly reduces atherosclerotic lesion area in mice.
| M.Wt | 369.67 | |
| Formula | C16H15Cl3N4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Ammirati M, et al. ACS Med Chem Lett. 2015 Oct 6;6(11):1128-33.
2. Roth Flach RJ, et al. Nat Commun. 2015 Dec 21;6:8995.
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