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Chemical Structure : PF-06372865
Catalog No.: PC-62089Not For Human Use, Lab Use Only.
PF-06372865 (Darigabat) is a novel potent, α2/3 functionally selective GABAA receptor positive allosteric modulator.
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PF-06372865 (Darigabat) is a novel potent, α2/3 functionally selective GABAA receptor positive allosteric modulator.
PF-06372865 (Darigabat) exhibits functional selectivity for receptors containing α2/3/5 subunits, with significant positive allosteric modulation (90-140%) but negligible activity (<20%) at GABAA receptors containing α1 subunits.
PF-06372865 (Darigabat) demonstrates a robust increase in saccadic peak velocity, increases in beta frequency qEEG and a slight saturating increase in body sway in clinical trials.
| M.Wt | 440.493 | |
| Formula | C22H21FN4O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Nickolls SA, et al. Br J Pharmacol. 2018 Feb;175(4):708-725.
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