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Chemical Structure : PF-06747711
CAS No.: 1892576-58-7
Catalog No.: PC-35596Not For Human Use, Lab Use Only.
PF-06747711 (PF06747711) is a potent, selective, orally bioavailable RORC2 (RORγt) inverse agonist with IC50 of 4.1 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $118 | In stock | |
| 10 mg | $178 | In stock | |
| 25 mg | $298 | In stock | |
| 50 mg | $498 | In stock | |
| 100 mg | Get quote |
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PF-06747711 (PF06747711) is a potent, selective, orally bioavailable RORC2 (RORγt) inverse agonist with IC50 of 4.1 nM.
PF-06747711 inhibits IL-17A production by human Th17 cells with IC50 of 9.5 nM.
PF-06747711 reduce levels of IL-17A in vivo after oral dosing in mice and corresponding reduction in skin inflammation.
| M.Wt | 497.522 | |
| Formula | C26H26F3N5O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
3-Cyano-N-(3-(1-isobutyrylpiperidin-4-yl)-1-methyl-4-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)benzamide |
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1. Schnute ME, et al. J Med Chem. 2018 Aug 21. doi: 10.1021/acs.jmedchem.8b00392.
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