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Chemical Structure : PF-06952229
Catalog No.: PC-72619Not For Human Use, Lab Use Only.
PF-06952229 (MDV6058) is a potent, selective and orally active TGFBR1 (ALK5) inhibitor with IC50 of 24 nM.
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PF-06952229 is a potent, selective and orally active TGFBR1 (ALK5) inhibitor with IC50 of 24 nM, specifically binds to TGFbR1 and prevents TGFbR1-mediated signal transduction (94% inhibition of pSMAD at 0.5 uM), shows with potential antineoplastic activity.
| M.Wt | 458.918 | |
| Formula | C23H24ClFN4O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Brahmam Pujala, et al. Bioorg Med Chem Lett. 2022 Sep 8;128979.
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