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Chemical Structure : PF-152
Catalog No.: PC-61148Not For Human Use, Lab Use Only.
PF-152 is a potent, highly selective and orally bioavailable MMP13 inhibitor with Ki of 1.5 nM, with no activity against MMP3 (Ki>10 uM).
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PF-152 is a potent, highly selective and orally bioavailable MMP13 inhibitor with Ki of 1.5 nM, with no activity against MMP3 (Ki>10 uM).
PF-152 also displays high selectivity against a panel of 14 matrix metalloproteinases, TACE, ADAMTS-4 and ADAMTS-5.
PF-152 suppresses MMP-13 mediated cartilage degradation in vivo, shows potential for treatment of oteoarthritis.
| M.Wt | 473.465 | |
| Formula | C21H24FN7O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Ruminski PG, et al. J Med Chem. 2016 Jan 14;59(1):313-27.
2. Settle S, et al. Arthritis Rheum. 2010 Oct;62(10):3006-15.
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