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Chemical Structure : PF-232798
Catalog No.: PC-61582Not For Human Use, Lab Use Only.
PF-232798 (PF-00232798) is a potent CCR5 antagonist with IC50 of <0.1 nM in gp160 fusion assay, exhibits potent broad-spectrum anti-HIV-1 activity.
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PF-232798 (PF-00232798) is a potent CCR5 antagonist with IC50 of <0.1 nM in gp160 fusion assay, exhibits potent broad-spectrum anti-HIV-1 activity.
PF-232798 shows no significant affinity for hERG (binding IC50>12 uM); demonstrates antiviral activity against HIV BaL in PBMCs with IC50 of 2.0 nM.
| M.Wt | 509.67 | |
| Formula | C29H40FN5O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Stupple PA, et al. J Med Chem. 2011 Jan 13;54(1):67-77.
2. Abrol R, et al. Proc Natl Acad Sci U S A. 2014 Sep 9;111(36):13040-5.
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