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Chemical Structure : PF-3450074
CAS No.: 1352879-65-2
Catalog No.: PC-63542Not For Human Use, Lab Use Only.
PF-3450074 (PF74) is a small molecule HIV capsid protein, destabilized the viral capsid in vitro.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $88 | In stock | |
| 25 mg | $138 | In stock | |
| 50 mg | $218 | In stock | |
| 100 mg | $378 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
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PF-3450074 (PF74) is a small molecule HIV capsid protein, destabilized the viral capsid in vitro.
PF-3450074 (PF74) acts at an early stage of HIV-1 infection and inhibits reverse transcription in target cells, induced the rapid dissolution of the HIV-1 capsid.
PF-3450074 (PF74) antiviral activity is promoted by binding of the host protein cyclophilin A to the HIV-1 capsid, and PF74 and cyclosporine exhibited mutual antagonism.
| M.Wt | 425.532 | |
| Formula | C27H27N3O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2-Methyl-N-[(1S)-2-(methylphenylamino)-2-oxo-1-(phenylmethyl)ethyl]- 1H-indole-3-acetamide |
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1. Shi J, et al. J Virol. 2011 Jan;85(1):542-9.
2. Shi J, et al. J Virol. 2015 Jan;89(1):208-19.
3. Zhou J, et al. J Virol. 2015 Sep;89(17):9068-79.
4. Saito A, et al. J Virol. 2016 May 27;90(12):5808-5823.
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