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Chemical Structure : PF-4693627
Catalog No.: PC-20721Not For Human Use, Lab Use Only.
PF-4693627 is a potent, selective and orally bioavailable mPGES-1 inhibitor with IC50 of 3 nM.
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PF-4693627 is a potent, selective and orally bioavailable mPGES-1 inhibitor with IC50 of 3 nM.
PF-4693627 exhibits an IC50 of 109 nM in LPS-stimulated human whole blood (HWB) cell assays, and IC50 of 6 nM in a fetal fibroblast cell assay.
PF-4693627 displays high selectivity over relevant human enzymes TXAS, PGDS, 5-LOX, 15-LOX and 12-LOX.
PF-4693627 (10 mg/kg, oral) is effective in a carrageenan-stimulated guinea pig air pouch model of inflammation.
| M.Wt | 502.44 | |
| Formula | C26H29Cl2N3O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Arhancet GB, et al. Bioorg Med Chem Lett. 2013 Feb 15;23(4):1114-9.
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