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Chemical Structure : PF-543
CAS No.: 1415562-82-1
Catalog No.: PC-35528Not For Human Use, Lab Use Only.
PF-543 (PF543) is a potent, specific, cell-permeant inhibitor of SphK1 with Ki of 3.6 nM, displays >100-fold selectivity over the SphK2 isoform.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $158 | In stock | |
| 25 mg | $258 | In stock | |
| 50 mg | $398 | In stock | |
| 100 mg | Get quote |
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PF-543 (PF543) is a potent, specific, cell-permeant inhibitor of SphK1 with Ki of 3.6 nM, displays >100-fold selectivity over the SphK2 isoform.
PF-543 decreases the level of endogenous S1P 10-fold with a proportional increase in the level of sphingosine in 1483 head and neck carcinoma cells.
PF-543 reduces sickling, hemolysis, and inflammation in SCD Tg mice by reducing erythrocyte SPHK1 activity and S1P levels.
PF-543 induces apoptosis, necrosis, and autophagy in human head and neck SCC cells.
| M.Wt | 465.608 | |
| Formula | C27H31NO4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(2R)-1-[[4-[[3-Methyl-5-[(phenylsulfonyl)methyl]phenoxy]methyl]phenyl]methyl]-2-pyrrolidinemethanol |
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1. Hamada M, et al. Cell Death Discov. 2017 Aug 14;3:17047.
2. Schnute ME, et al. Biochem J. 2012 May 15;444(1):79-88.
3. Zhang Y, et al. J Clin Invest. 2014 Jun;124(6):2750-61.
4. Wang J, et al. ACS Med Chem Lett. 2014 Oct 27;5(12):1329-33.
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