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Chemical Structure : PF-8380
CAS No.: 1144035-53-9
Catalog No.: PC-43508Not For Human Use, Lab Use Only.
PF-8380 is a potent, specific, orally active Autotaxin inhibitor with IC50 of 2.8 and 101 nM in enzyme assay and in human whole blood assay, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $88 | In stock | |
| 25 mg | $148 | In stock | |
| 50 mg | $248 | In stock | |
| 100 mg | Get quote |
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PF-8380 is a potent, specific, orally active Autotaxin inhibitor with IC50 of 2.8 and 101 nM in enzyme assay and in human whole blood assay, respectively.
PF-8380 produces >95% reduction in both plasma and air pouch lysophosphatidic acid (LPA) within 3 h by dosed orally at 30 mg/kg in rat air pouch model.
PF-8380 reduces inflammatory hyperalgesia in vivo.
PF-8380 also enhances the radiosensitivity of human and murine glioblastoma cell lines.
| M.Wt | 478.33 | |
| Formula | C22H21Cl2N3O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
1-Piperazinecarboxylic acid, 4-[3-(2,3-dihydro-2-oxo-6-benzoxazolyl)-3-oxopropyl]-, (3,5-dichlorophenyl)methyl ester |
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1. Gierse J, et al. J Pharmacol Exp Ther. 2010 Jul;334(1):310-7.
2. Bhave SR, et al. Front Oncol. 2013 Sep 17;3:236.
3. St-Cœur PD, et al. Arch Pharm (Weinheim). 2013 Feb;346(2):91-7.
4. Navab M, et al. J Lipid Res. 2015 Apr;56(4):871-87.
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