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Chemical Structure : PF-AKT400
CAS No.: 1004990-28-6
Catalog No.: PC-42697Not For Human Use, Lab Use Only.
PF-AKT400 is a broadly selective, potent, ATP-competitive Akt kinase inhibitor with IC50 of 0.5 nM (biochemical assay), and 0.31 nM (cell function assay).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $258 | In stock | |
| 10 mg | $388 | In stock | |
| 25 mg | Get quote | ||
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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PF-AKT400 is a broadly selective, potent, ATP-competitive Akt kinase inhibitor with IC50 of 0.5 nM (biochemical assay), and 0.31 nM (cell function assay).
PF-AKT400 shows >900-fold selectivity over PKA.
PF-AKT400 shows excellent PK profiles and effective in in vivo models of xenograft tumor.
| M.Wt | 400.4251 | |
| Formula | C20H22F2N6O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Benzamide, N-[[(3S)-3-amino-1-(5-ethyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-3-pyrrolidinyl]methyl]-2,4-difluoro- |
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1. Freeman-Cook KD, et al. J Med Chem. 2010 Jun 24;53(12):4615-22.
2. Chen SF, et al. J Mol Model. 2013 Nov;19(11):5097-112.
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