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Chemical Structure : PFM39
CAS No.: 1310744-67-2
Catalog No.: PC-61925Not For Human Use, Lab Use Only.
PFM39 (SML1839) is a small molecule that specifically inhibits exonuclease activity of MRE11, binds in the active site similar to mirin, inhibits dsDNA end resection in A549 cells with IC50 of 50-75 uM, inhibits HR without significantly increasing NHEJ..
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $148 | In stock | |
| 25 mg | $238 | In stock | |
| 50 mg | $398 | In stock | |
| 100 mg | Get quote |
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PFM39 (SML1839) is a small molecule that specifically inhibits exonuclease activity of MRE11, binds in the active site similar to mirin, inhibits dsDNA end resection in A549 cells with IC50 of 50-75 uM, inhibits HR without significantly increasing NHEJ.
| M.Wt | 219.262 | |
| Formula | C10H9N3OS | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(5Z)-2-Amino-5-[(4-aminophenyl)methylene]-4(5H)-thiazolone |
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1. Shibata A, et al. Mol Cell. 2014 Jan 9;53(1):7-18.
2. Hengel SR, et al. Cell Chem Biol. 2017 Sep 21;24(9):1101-1119.
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