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Chemical Structure : PHCCC
CAS No.: 179068-02-1
Catalog No.: PC-42140Not For Human Use, Lab Use Only.
A potent, selective allosteric potentiator of mGluR4 with EC50 of 4.1 uM, also is aselective antagonist of group mGlu1 receptors.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $80 | In stock | |
| 25 mg | $176 | In stock | |
| 50 mg | $304 | In stock | |
| 100 mg | $528 | In stock |
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A potent, selective allosteric potentiator of mGluR4 with EC50 of 4.1 uM, also is aselective antagonist of group mGlu1 receptors; potentiates the response to glutamate (2 uM) 5.6-fold compared with glutamate alone in FLIPR assay; shows significant, dose-dependent anticonflict effects without affecting the threshold current or water intake in rats; also reduces proliferation and promotes differentiation of cerebellar granule cell neuroprecursors in rats.
| M.Wt | 294.3047 | |
| Formula | C17H14N2O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 32 mg/mL |
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| Chemical Name/SMILES |
Benzo[b]cyclopropa[e]pyran-1a(1H)-carboxamide, 7,7a-dihydro-7-(hydroxyimino)-N-phenyl- |
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1. Stachowicz K, et al. Eur J Pharmacol. 2004 Sep 13;498(1-3):153-6.
2. Canudas AM, et al. J Neurosci. 2004 Nov 17;24(46):10343-52.
3. Marino MJ, et al. Proc Natl Acad Sci U S A. 2003 Nov 11;100(23):13668-73.
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