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PI3K inhibitor X

Chemical Structure : PI3K inhibitor X

CAS No.: 956958-53-5

PI3K inhibitor X (XL-147 analog)

Catalog No.: PC-42812Not For Human Use, Lab Use Only.

PI3K inhibitor X (XL-147 analog) is a derivative of XL147 that acts as a reversible inhibitor of class I PI3Ks with IC50 of 39, 36, 23 and 383 nM for p110α, δ, γ and β respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

PI3K inhibitor X (XL-147 analog) is a derivative of XL147 that acts as a reversible inhibitor of class I PI3Ks with IC50 of 39, 36, 23 and 383 nM for p110α, δ, γ and β respectively; Compound 147 in patent WO2012006552A1.

Physicochemical Properties

M.Wt 448.5208
Formula C21H16N6O2S2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

Benzenesulfonamide, N-[3-(2,1,3-benzothiadiazol-5-ylamino)-2-quinoxalinyl]-4-methyl-

References

1. Carlos L. Arteaga, et al. Combinations of kinase inhibitors for the treatment of cancer. WO 2012006552 A1.

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