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Chemical Structure : PI3Kα-IN-4h
Catalog No.: PC-62843Not For Human Use, Lab Use Only.
PI3Kα-IN-1 is a potent, selective, ATP-competitive dual PI3Kα/mTOR inhibitor with IC50 of 0.5/104 nM respectively.
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PI3Kα-IN-1 is a potent, selective, ATP-competitive dual PI3Kα/mTOR inhibitor with IC50 of 0.5/104 nM respectively; displays good selectivity for PI3Kα; demonstrates cytotoxicity in MCF7 cells, reasonable toxicity in MDA-MB-468 cells, good therapeutic index compared to normal skin fibroblasts, and acceptable in vitro ADME properties.
| M.Wt | 483.532 | |
| Formula | C26H25N7O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Al-Ashmawy AAK, et al. Bioorg Med Chem Lett. 2017 Jul 15;27(14):3117-3122.
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